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Details on Person Transmembrane O-methyltransferase (LRTOMT aka COMT2) catalys...
| Class:Id | Summation:8955005 |
|---|---|
| _displayName | Transmembrane O-methyltransferase (LRTOMT aka COMT2) catalys... |
| _timestamp | 2017-01-10 11:52:17 |
| created | [InstanceEdit:8955016] Jassal, Bijay, 2017-01-10 |
| text | Transmembrane O-methyltransferase (LRTOMT aka COMT2) catalyses the O-methylation of catecholamine neurotransmitters, thereby inactivating them (Du et al. 2008). LRTOMT is highly expressed in sensory hair cells of the inner ear. Defects in LRTOMT can cause autosomal recessive deafness 63 (DFNB63), a form of non-syndromic sensorineural hearing loss (Ahmed et al. 2008, Du et al. 2008). In this example, dopamine (DA) is O-methylated using S-adenosyl-L-methionine (AdoMet) as the methyl donor to form 3-methyltyramine (3MT) and S-adenosyl-L-homocysteine (AdoHcy). |
| (summation) | [Reaction:8955010] LRTOMT transfers Met to DA, forming 3MT [Homo sapiens] |
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No pathways have been reviewed or authored by Transmembrane O-methyltransferase (LRTOMT aka COMT2) catalys... (8955005)
