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Details on Person PLD6 dimer hydrolyses cardiolipin to PA and PG

Class:Id	Reaction:8954398
_displayName	PLD6 dimer hydrolyses cardiolipin to PA and PG
_doRelease	TRUE
_timestamp	2017-01-11 15:47:22
authored	[InstanceEdit:8954396] Jassal, Bijay, 2017-01-09
catalystActivity	[CatalystActivity:8954400] cardiolipin phospholipase D activity of PLD6 dimer [mitochondrial outer membrane]
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:8954396] Jassal, Bijay, 2017-01-09
edited	[InstanceEdit:8954396] Jassal, Bijay, 2017-01-09
input	[SimpleEntity:8954419] cardiolipin [mitochondrial outer membrane] [SimpleEntity:189422] H2O [mitochondrial intermembrane space]
isChimeric	FALSE
literatureReference	[LiteratureReference:5629236] A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis [LiteratureReference:8954425] Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response [LiteratureReference:8954424] Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis
modified	[InstanceEdit:8954416] Jassal, Bijay, 2017-01-09 [InstanceEdit:8954422] Jassal, Bijay, 2017-01-09 [InstanceEdit:8954433] Jassal, Bijay, 2017-01-09 [InstanceEdit:8955386] Jassal, Bijay, 2017-01-11 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PLD6 dimer hydrolyses cardiolipin to PA and PG
output	[SimpleEntity:1500590] PA [mitochondrial outer membrane] [SimpleEntity:8954401] PG [mitochondrial outer membrane]
regulatedBy	[PositiveRegulation:8954403] Positive regulation by 'MIGA complexes [mitochondrial outer membrane]'
releaseDate	2017-03-27
reviewed	[InstanceEdit:8955387] D'Eustachio, Peter, 2017-01-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8954410] R-HSA-8954398.3
summation	[Summation:8954428] Mitochondrial cardiolipin hydrolase (PLD6 aka MitoPLD) is lo...
(hasEvent)	[Pathway:1483166] Synthesis of PA [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens]
(precedingEvent)	[Reaction:1483099] PA translocates from the outer to the inner mitochondrial membrane [Homo sapiens]
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No pathways have been reviewed or authored by PLD6 dimer hydrolyses cardiolipin to PA and PG (8954398)