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Details on Person NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex

Class:IdReaction:8952639
_displayNameNEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
_doReleaseTRUE
_timestamp2017-02-28 16:44:26
authored[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:8952636] Rothfels, Karen, 2016-12-15
edited[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
input[Complex:8952569] NEDD8-AcM-UBE2M [nucleoplasm] [Homo sapiens]
[Complex:8955268] CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] [Homo sapiens]
[CandidateSet:8952551] DCUN1D1,2,4,5 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:8952185] E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
[LiteratureReference:8952007] Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes
[LiteratureReference:8952191] SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
[LiteratureReference:8952178] Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation
[LiteratureReference:8952208] The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes
[LiteratureReference:8952170] Characterization of the mammalian family of DCN-type NEDD8 E3 ligases
[LiteratureReference:8955468] SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)
[LiteratureReference:5690803] Protein neddylation: beyond cullin-RING ligases
[LiteratureReference:8955148] Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B
[LiteratureReference:8955171] The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications
[LiteratureReference:8953189] Cullin E3 ligases and their rewiring by viral factors
modified[InstanceEdit:8952652] Rothfels, Karen, 2016-12-15
[InstanceEdit:8955322] Rothfels, Karen, 2017-01-10
[InstanceEdit:8955480] Rothfels, Karen, 2017-01-11
[InstanceEdit:8955506] Rothfels, Karen, 2017-01-11
[InstanceEdit:8956058] Rothfels, Karen, 2017-01-13
[InstanceEdit:8961958] Rothfels, Karen, 2017-02-06
[InstanceEdit:8979152] Rothfels, Karen, 2017-02-21
[InstanceEdit:8980624] Rothfels, Karen, 2017-02-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
output[Complex:8952580] NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2017-03-27
reviewed[InstanceEdit:8979124] Pick, Elah, 2017-02-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8952640] R-HSA-8952639.2
summation[Summation:8955256] UBE2M is the E2 for CRL complexes containing cullin 1, 2, 3 ...
(hasEvent)[Pathway:8951664] Neddylation [Homo sapiens]
(precedingEvent)[Reaction:8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex [Homo sapiens]
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