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Details on Person RUNX proteins bind the p14-ARF promoter at the CDKN2A locus

Class:Id	Reaction:8952081
_displayName	RUNX proteins bind the p14-ARF promoter at the CDKN2A locus
_doRelease	TRUE
_timestamp	2017-01-31 16:55:45
authored	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8952085] Orlic-Milacic, Marija, 2016-12-12
edited	[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
input	[CandidateSet:8952092] RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3200017] CDKN2A gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8952095] The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia [LiteratureReference:8951941] Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma
modified	[InstanceEdit:8959882] Orlic-Milacic, Marija, 2017-01-31 [InstanceEdit:8959887] Orlic-Milacic, Marija, 2017-01-31 [InstanceEdit:8959889] Orlic-Milacic, Marija, 2017-01-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX proteins bind the p14-ARF promoter at the CDKN2A locus
output	[Complex:8952078] RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2):CDKN2A gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8951977] Acetylated RUNX3 binds to BRD2 [Homo sapiens] [Reaction:8951966] EP300 acetylates RUNX3 [Homo sapiens] [Reaction:8865320] CBFB binds RUNX1 [Homo sapiens] [BlackBoxEvent:8935785] RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8952098] R-HSA-8952081.2
summation	[Summation:8952094] The CDKN2A gene promoter that regulates transcription of p14...
(hasEvent)	[Pathway:8951936] RUNX3 regulates p14-ARF [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8952101] p14-ARF transcription is stimulated by RUNX proteins [Homo sapiens]
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No pathways have been reviewed or authored by RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (8952081)