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Details on Person AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex

Class:Id	Reaction:8952044
_displayName	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
_doRelease	TRUE
_timestamp	2017-02-28 16:42:09
authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
catalystActivity	[CatalystActivity:8952043] NEDD8 transferase activity of NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8952045] Rothfels, Karen, 2016-12-12
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
input	[Complex:8952026] NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8952201] Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation [LiteratureReference:5691194] Covalent modification of all members of human cullin family proteins by NEDD8 [LiteratureReference:8952206] TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes [LiteratureReference:8955140] Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery [LiteratureReference:192252] Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation [LiteratureReference:8955179] The role of cullin 5-containing ubiquitin ligases [LiteratureReference:8953189] Cullin E3 ligases and their rewiring by viral factors
modified	[InstanceEdit:8952612] Rothfels, Karen, 2016-12-15 [InstanceEdit:8955291] Rothfels, Karen, 2017-01-10 [InstanceEdit:8961958] Rothfels, Karen, 2017-02-06 [InstanceEdit:8979131] Rothfels, Karen, 2017-02-21 [InstanceEdit:8980603] Rothfels, Karen, 2017-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
output	[EntityWithAccessionedSequence:8951623] AcM-UBE2F [cytosol] [Homo sapiens] [Complex:8952024] NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8952039] NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex [Homo sapiens] [Reaction:8951764] Transfer of NEDD8 to AcM-UBE2F [Homo sapiens] [Reaction:8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8952046] R-HSA-8952044.2
summation	[Summation:8952611] UBE2F transfers NEDD8 to lysine 724 of CUL5 in the E3 ligase...
(hasEvent)	[Pathway:8951664] Neddylation [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9767179] Futile Cycle: AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex [Reaction:8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes [Homo sapiens]
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No pathways have been reviewed or authored by AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (8952044)