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Details on Person EP300 acetylates RUNX3

Class:IdReaction:8951966
_displayNameEP300 acetylates RUNX3
_doReleaseTRUE
_timestamp2017-01-31 16:55:43
authored[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
catalystActivity[CatalystActivity:8951961] protein-lysine-acetyltransferase activity of RUNX3:CBFB:EP300 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:8951962] Orlic-Milacic, Marija, 2016-12-12
edited[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
input[Complex:8951952] RUNX3:CBFB:EP300 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113560] Ac-CoA [nucleoplasm]
[SimpleEntity:113560] Ac-CoA [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:8951941] Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma
[LiteratureReference:8951953] Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
modified[InstanceEdit:8951974] Orlic-Milacic, Marija, 2016-12-12
[InstanceEdit:8959882] Orlic-Milacic, Marija, 2017-01-31
[InstanceEdit:8959887] Orlic-Milacic, Marija, 2017-01-31
[InstanceEdit:8959889] Orlic-Milacic, Marija, 2017-01-31
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameEP300 acetylates RUNX3
output[Complex:8951959] Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] [Homo sapiens]
[SimpleEntity:2485002] CoA-SH [nucleoplasm]
[SimpleEntity:2485002] CoA-SH [nucleoplasm]
precedingEvent
regulatedBy[PositiveRegulation:8951975] Positive regulation by 'Dimeric TGFB1 [extracellular region]'
regulationReference[RegulationReference:9641619] Positive regulation by 'Dimeric TGFB1 [extracellular region]' Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
releaseDate2017-03-27
reviewed[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31
[InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8951969] R-HSA-8951966.4
summation[Summation:8951973] EP300 (p300) histone acetyltransferase acetylates RUNX3 on l...
(hasEvent)[Pathway:8951936] RUNX3 regulates p14-ARF [Homo sapiens]
(precedingEvent)[Reaction:8951977] Acetylated RUNX3 binds to BRD2 [Homo sapiens]
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No pathways have been reviewed or authored by EP300 acetylates RUNX3 (8951966)