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Details on Person p-VAV family:PIP3 binds RAC1:GDP

Class:Id	Reaction:8951586
_displayName	p-VAV family:PIP3 binds RAC1:GDP
_doRelease	TRUE
_timestamp	2017-10-24 15:21:48
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8951589] Jupe, Steve, 2016-12-08
edited	[InstanceEdit:8951592] Jupe, Steve, 2016-12-08
input	[Complex:5218789] p-VAV family:PIP3 [plasma membrane] [Homo sapiens] [Complex:5674631] RAC1:GDP [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5218543] VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2
modified	[InstanceEdit:8951592] Jupe, Steve, 2016-12-08 [InstanceEdit:8951715] Jupe, Steve, 2016-12-09 [InstanceEdit:9026952] Rothfels, Karen, 2017-10-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-VAV family:PIP3 binds RAC1:GDP
output	[Complex:8951587] p-VAV family:PIP3:RAC1:GDP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5218820] Src kinases phosphorylate VAV [Homo sapiens] [Reaction:434637] PI(3,4,5)P3 binds VAV1,2,3 [Homo sapiens] [Reaction:5218645] SRC-1 binds p-Y397-PTK2 [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8951590] R-HSA-8951586.3
summation	[Summation:8951716] Tyrosine-phosphorylated VAVs bind RAC1:GDP as RAC1 guanine n...
(hasEvent)	[Pathway:4420097] VEGFA-VEGFR2 Pathway [Homo sapiens]
(precedingEvent)	[Reaction:5218850] VAV exchanges GTP for GDP on RAC1, activating it [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780277] Update Tracker - [Reaction:8951586] p-VAV family:PIP3 binds RAC1:GDP - v63:[add_removeInput] [_UpdateTracker:9864125] Update Tracker - [Reaction:8951586] p-VAV family:PIP3 binds RAC1:GDP - v88:[modifyText]
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No pathways have been reviewed or authored by p-VAV family:PIP3 binds RAC1:GDP (8951586)