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Details on Person Interleukin-27 heterodimer (IL27) binds a heterodimeric rece...
| Class:Id | Summation:8950764 |
|---|---|
| _displayName | Interleukin-27 heterodimer (IL27) binds a heterodimeric rece... |
| _timestamp | 2017-05-18 13:29:05 |
| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
| literatureReference | [LiteratureReference:8950167] IL-27 Promotes Proliferation of Human Leukemic Cell Lines Through the MAPK/ERK Signaling Pathway and Suppresses Sensitivity to Chemotherapeutic Drugs |
| modified | [InstanceEdit:9006421] Duenas, Corina, 2017-05-16 [InstanceEdit:9006617] Jupe, Steve, 2017-05-17 [InstanceEdit:9006733] Duenas, Corina, 2017-05-18 |
| text | Interleukin-27 heterodimer (IL27) binds a heterodimeric receptor formed by Interleukin-27 subunit alpha (IL27RA) and Interleukin-6 receptor subunit beta (IL6ST, gp130). In the absence of IL27RA IL27 can bind IL6ST with low affinity. Dissociation rate constants for binding of IL27 to the heterodimeric receptor indicate a slow dissociation rate, resulting in very high binding affinity. Blocking both receptor chains completely blocks IL27 induced STAT1 and STAT3 phosphorylation and IL27 induced proliferation (Jia et al. 2016). |
| (summation) | [Reaction:8950210] Interleukin-27 dissociates from Interleukin-27 receptor [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukin-27 heterodimer (IL27) binds a heterodimeric rece... (8950764)
