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Details on Person Interleukin 27 alpha subunit (IL27, IL 27p28) can bind Cytok...

Class:IdSummation:8950762
_displayNameInterleukin 27 alpha subunit (IL27, IL 27p28) can bind Cytok...
_timestamp2017-03-01 14:36:34
created[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
literatureReference[LiteratureReference:8950401] The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
modified[InstanceEdit:8981121] Duenas, Corina, 2017-03-01
textInterleukin 27 alpha subunit (IL27, IL 27p28) can bind Cytokine receptor like factor 1 (CRLF1). IL27 has greatest homology with Interleukin 11 (IL11) and CRLF1. The IL27:CRLF1 complex is produced in dendritic cells and stimulates Natural Killer (NK) cells, increasing Interleukin 12 and Interleukin 2 induced Interferon gamma (IFNG) production and activation of marker expression.

Experiments with Ba/F3 transfectants indicate that IL27:CRLF1 activates cells expressing Interleukin 6 receptor subunit alpha (IL6R) in addition to the Interleukin 27 receptor subunits WSX1 and gp130. When tested on CD4+ and CD8+ T cells, IL27:CRLF1 induces Interleukin 6 receptor subunit alpha (IL6RA) dependent Signal transducer and activator of transcription 1 alpha/beta (STAT1) and STAT3 phosphorylation (Crabé et al. 2009). This reaction is a Black Box event since we know this complex forms and is secreted but do not know the compartment where dimer formation takes place.
(summation)[BlackBoxEvent:8950504] IL27 binds CRLF1 [Homo sapiens]
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