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Details on Person Interleukin 27 alpha subunit (IL27,IL27A, IL27p28) and Cytok...
| Class:Id | Summation:8950671 |
|---|---|
| _displayName | Interleukin 27 alpha subunit (IL27,IL27A, IL27p28) and Cytok... |
| _timestamp | 2017-03-01 14:34:11 |
| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
| literatureReference | [LiteratureReference:8950401] The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling |
| modified | [InstanceEdit:8981113] Duenas, Corina, 2017-03-01 |
| text | Interleukin 27 alpha subunit (IL27,IL27A, IL27p28) and Cytokine like factor 1 (CRLF1) form a secreted complex. Secretion of IL27 was observed in HEK 293 cells transfected with IL27 cDNA in the absence of CRLF1. This may indicate that formation of a complex is not strictly required for IL27 secretion in these cells. Alternatively it could reflect the formation of a complex between IL27 and endogenous CRLF1, which is expressed in HEK 293 cells. The IL27:CRLF1 complex is biologically active (Crabé et al. 2009). This reaction is a black box event because the mechanism of translocation is unknown. |
| (summation) | [Complex:8950767] CRLF1:IL27 [extracellular region] [Homo sapiens] [BlackBoxEvent:8950731] CRLF1:IL27 translocates to the extracellular region [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukin 27 alpha subunit (IL27,IL27A, IL27p28) and Cytok... (8950671)
