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Details on Person JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated

Class:Id	BlackBoxEvent:8950591
_displayName	JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
_doRelease	TRUE
_timestamp	2017-09-12 10:12:18
authored	[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
catalystActivity	[CatalystActivity:9006666] transmembrane receptor protein tyrosine kinase activity of IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
edited	[InstanceEdit:9005965] Duenas, Corina, 2017-05-11
inferredFrom	[BlackBoxEvent:8950612] Jak2, Tyk2 in Il12b:Il23a:Il12rb1:Tyk2:Il23r:Jak2 are phosphorylated [Mus musculus]
input	[Complex:447186] IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
modified	[InstanceEdit:8952740] Duenas, Corina, 2016-12-16 [InstanceEdit:9005636] Duenas, Corina, 2017-05-09 [InstanceEdit:9006072] Duenas, Corina, 2017-05-12 [InstanceEdit:9006348] Duenas, Corina, 2017-05-13 [InstanceEdit:9006668] Duenas, Corina, 2017-05-17 [InstanceEdit:9020934] Jupe, Steve, 2017-09-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated JAK2 and TYK2 activation after IL23:IL23R interaction
output	[Complex:8950239] IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2017-06-12
reviewed	[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8950959] R-HSA-8950591.3
summation	[Summation:8950274] In human cells IL-23 binding leads to phosphorylation and ac...
(hasEvent)	[Pathway:9020933] Interleukin-23 signaling [Homo sapiens]
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No pathways have been reviewed or authored by JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (8950591)