Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Interleukin-12 subunit alpha (IL12A, IL12p35) binds Interleu...
| Class:Id | Summation:8950494 |
|---|---|
| _displayName | Interleukin-12 subunit alpha (IL12A, IL12p35) binds Interleu... |
| _timestamp | 2017-05-16 13:59:41 |
| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
| literatureReference | [LiteratureReference:8949818] Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin |
| modified | [InstanceEdit:8952737] Duenas, Corina, 2016-12-16 [InstanceEdit:9006421] Duenas, Corina, 2017-05-16 |
| text | Interleukin-12 subunit alpha (IL12A, IL12p35) binds Interleukin-27 subunit beta (EBI3) forming the Interleukin-35 heterodimeric complex (IL12A:EBI3)(Devergne et al.). When expressed alone, human EBI3 is associated with the endoplasmic reticulum (ER) resident molecular chaperone calnexin (CANX) and is retained in the ER (Devergne et al. 1997). Co-expression of IL27 and EBI3 enables formation of IL27:EBI3, allowing secretion (Pflanz et al. 2002). This is a Black Box event because there is not reported wich reaction occurs first: the association of IL12A to EBI3:CANX and later the Interleukin-35 heterodimeric protein formation. |
| (summation) | [BlackBoxEvent:8950740] CANX dissociates from IL12A:EBI3 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Interleukin-12 subunit alpha (IL12A, IL12p35) binds Interleu... (8950494)
