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Details on Person Interleukin-23 receptor signaling leads to Signal transducer...
| Class:Id | Summation:8950469 |
|---|---|
| _displayName | Interleukin-23 receptor signaling leads to Signal transducer... |
| _timestamp | 2017-05-18 13:29:03 |
| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
| literatureReference | [LiteratureReference:447185] A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R [LiteratureReference:8950691] Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 [LiteratureReference:8950351] Genetic susceptibility to invasive Salmonella disease |
| modified | [InstanceEdit:8981116] Duenas, Corina, 2017-03-01 [InstanceEdit:9006617] Jupe, Steve, 2017-05-17 [InstanceEdit:9006733] Duenas, Corina, 2017-05-18 |
| text | Interleukin-23 receptor signaling leads to Signal transducer and activator of transcription 3/Signal transducer and activator of transcription 4 (STAT3:STAT4) heterodimer activation in addition to the activation of STAT3 homodimers. Although Interleukin 23 activates the same spectrum of JAK/STAT molecules as interleukin 12, Interleukin-23 activates STAT4 to a lesser extent (Oppmann et al. 2000, Parham et al. 2012). The STAT3:STAT4 heterodimer translocates to the nucleus. This reaction is presented as a black box event because the exact mechanism of translocation to the nucleus is unknown. |
| (summation) | [BlackBoxEvent:8950724] p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukin-23 receptor signaling leads to Signal transducer... (8950469)
