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Details on Person Interleukin-23 (IL23) induces Signal transducer and activato...
| Class:Id | Summation:8950445 |
|---|---|
| _displayName | Interleukin-23 (IL23) induces Signal transducer and activato... |
| _timestamp | 2017-05-24 16:06:12 |
| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
| literatureReference | [LiteratureReference:447185] A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R [LiteratureReference:9006417] IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12 |
| modified | [InstanceEdit:8952683] Duenas, Corina, 2016-12-16 [InstanceEdit:9006421] Duenas, Corina, 2017-05-16 [InstanceEdit:9006625] Jupe, Steve, 2017-05-17 [InstanceEdit:9006674] Jupe, Steve, 2017-05-17 [InstanceEdit:9006961] Jupe, Steve, 2017-05-24 |
| text | Interleukin-23 (IL23) induces Signal transducer and activator of transcription 3 (STAT3) and STAT4 phosphorylation. Non-receptor tyrosine-protein kinase TYK2 (TYK2) and Tyrosine-protein kinase JAK2 (JAK2) are believed to phosphorylate STAT3 and STAT4 (Parham et al. 2002). STAT3 is the most prominent STAT activated by IL23, contrasting with Interleukin-12 (IL12) which predominantly induces STAT4 activation (Parham et al. 2002). IL23 induces phosphorylation of STAT3 and STAT4 in NK-like T cells but neither in NK cells (van de Wetering et al. 2009). Phosphorylation results in STAT3:STAT4 heterodimer formation (Parham et al. 2002). This is a black box event because the exact mechanism and order of STAT3/STAT4 binding is unknown. |
| (summation) | [BlackBoxEvent:8950269] STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor [Homo sapiens] |
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