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Details on Person Signal transducer and activator of transcription 1-alpha/bet...
| Class:Id | Summation:8950371 |
|---|---|
| _displayName | Signal transducer and activator of transcription 1-alpha/bet... |
| _timestamp | 2017-05-17 13:40:45 |
| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
| literatureReference | [LiteratureReference:448414] WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 [LiteratureReference:8981082] IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells [LiteratureReference:8950167] IL-27 Promotes Proliferation of Human Leukemic Cell Lines Through the MAPK/ERK Signaling Pathway and Suppresses Sensitivity to Chemotherapeutic Drugs |
| modified | [InstanceEdit:8952736] Duenas, Corina, 2016-12-16 [InstanceEdit:8981104] Duenas, Corina, 2017-03-01 [InstanceEdit:9006625] Jupe, Steve, 2017-05-17 |
| text | Signal transducer and activator of transcription 1-alpha/beta (STAT1) and STAT3 are both known to be phosphorylated by Interleukin-27 (IL27) in human cells (Hibbert et al. 2003). Interleukin-27 receptor beta subunit (IL6ST, gp130) activation after IL27 stimulation leads to STAT activation. It is thought that the IL27RA subunit of the Interleukin 27 receptor complex contributes more to STAT1 tyrosine phosphorylation and IL6ST to STAT3 tyrosine phosphorylation (Pflanz et al. 2004). Blocking both the IL27RA and IL6ST receptor chains completely blocks IL27 induced STAT1 and STAT3 phosphorylation and IL27 induced proliferation (Jia et al. 2016). As the pattern of phosphorylation events involved in this event is uncertain it is represented here as a black box event. |
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No pathways have been reviewed or authored by Signal transducer and activator of transcription 1-alpha/bet... (8950371)
