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Details on Person Interleukin 27 subunit alpha (IL27, IL-27p28) binds Interleu...

Class:IdSummation:8950352
_displayNameInterleukin 27 subunit alpha (IL27, IL-27p28) binds Interleu...
_timestamp2017-05-16 13:59:35
created[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
literatureReference[LiteratureReference:448474] IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
[LiteratureReference:8950462] A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
modified[InstanceEdit:8981112] Duenas, Corina, 2017-03-01
[InstanceEdit:9006421] Duenas, Corina, 2017-05-16
textInterleukin 27 subunit alpha (IL27, IL-27p28) binds Interleukin 27 subunit beta (EBI3) forming the Interleukin 27 heterodimeric complex (IL27:EBI3). When expressed alone, human EBI3 is associated with the endoplasmic reticulum (ER) resident molecular chaperone calnexin (CANX) and is retained in the ER (Devergne et al 1996). Co expression of IL27 and EBI3 enables formation of IL27:EBI3, allowing secretion (Pflanz et al. 2002).

This is a Black Box event because there is not reported which reaction occurs first: the association of IL27 to EBI3:CANX and later the Interleukin 27 heterodimeric protein formation or first the dissociation of EBI3 from CANX and later formation of the Interleukin 27 heterodimeric protein formation. Since the EBI3 is retained in the endoplasmic reticulum as a complex with CANX (Devergne et al. 1996), and the co expression of IL27 and EBI3 enable the formation of the Interleukin 27 heterodimeric complex formation, allowing secretion of this protein (Pflanz et al. 2002).
(summation)[BlackBoxEvent:8950342] EBI3:CANX binds IL27 [Homo sapiens]
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