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Details on Person IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation

Class:Id	BlackBoxEvent:8950340
_displayName	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
_doRelease	TRUE
_timestamp	2017-09-12 14:31:25
authored	[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
catalystActivity	[CatalystActivity:9006670] transmembrane receptor protein tyrosine kinase activity of IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
edited	[InstanceEdit:9005965] Duenas, Corina, 2017-05-11
input	[Complex:8950252] IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:448414] WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 [LiteratureReference:8950165] Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment [LiteratureReference:8950097] IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes
modified	[InstanceEdit:8952680] Duenas, Corina, 2016-12-16 [InstanceEdit:9005636] Duenas, Corina, 2017-05-09 [InstanceEdit:9006072] Duenas, Corina, 2017-05-12 [InstanceEdit:9006348] Duenas, Corina, 2017-05-13 [InstanceEdit:9006668] Duenas, Corina, 2017-05-17 [InstanceEdit:9020957] Jupe, Steve, 2017-09-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
output	[Complex:8950331] IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2017-06-12
reviewed	[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8950927] R-HSA-8950340.3
summation	[Summation:8950529] Interleukin-27 receptor is formed by Interleukin-27 receptor...
(hasEvent)	[Pathway:9020956] Interleukin-27 signaling [Homo sapiens]
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No pathways have been reviewed or authored by IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (8950340)