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Details on Person Interleukin-23 (IL23) signaling predominantly leads to forma...
| Class:Id | Summation:8950309 |
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| _displayName | Interleukin-23 (IL23) signaling predominantly leads to forma... |
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| _timestamp | 2017-05-18 13:29:01 |
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| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
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| literatureReference | [LiteratureReference:447185] A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R |
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| modified | [InstanceEdit:8981118] Duenas, Corina, 2017-03-01
[InstanceEdit:9006421] Duenas, Corina, 2017-05-16
[InstanceEdit:9006617] Jupe, Steve, 2017-05-17
[InstanceEdit:9006674] Jupe, Steve, 2017-05-17
[InstanceEdit:9006733] Duenas, Corina, 2017-05-18 |
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| text | Interleukin-23 (IL23) signaling predominantly leads to formation of Signal transducer and activator of transcription 3 (STAT3) homodimers while also heterodimers of STAT3 and STAT4 can also be formed (Parham et al. 2002). The STAT4 phosphorylation induced by IL23 is much weaker than induced in response to Interleukin-12. |
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| (summation) | [Reaction:8950780] p-Y705-STAT3 binds p-Y693-STAT4 [Homo sapiens] |
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