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Details on Person IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane]

Class:Id	Complex:8950255
_displayName	IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane]
_timestamp	2017-04-16 01:50:08
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
hasComponent	[Complex:622267] IL35 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:448418] EBI3 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:447212] IL12A [extracellular region] [Homo sapiens] [Complex:8950302] IL12RB2:p-JAK2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:210621] p-JAK2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:447249] IL12RB2 [plasma membrane] [Homo sapiens] [Complex:8950664] IL6ST:p-JAK1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8950711] p-JAK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:448453] IL6ST [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6809152] IL-12 family cytokines: immunological playmakers
modified	[InstanceEdit:8985450] Varusai, Thawfeek, 2017-04-16
name	IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8950947] R-HSA-8950255.1
(hasComponent)	[Complex:8952780] IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] [Homo sapiens] [Complex:8952787] STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] [Homo sapiens]
(input)	[BlackBoxEvent:8952786] STAT1 binds active IL6ST:IL12RB2 heterodimer [Homo sapiens] [BlackBoxEvent:8983996] STAT1 and STAT4 associate with IL12RB2:IL6ST receptor [Homo sapiens]
(output)	[BlackBoxEvent:8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated [Homo sapiens] [BlackBoxEvent:8983983] p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor [Homo sapiens]
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No pathways have been reviewed or authored by IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (8950255)