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Details on Person Monocytes express the Interleukin-27 receptor and in respons...
| Class:Id | Summation:8950232 |
|---|---|
| _displayName | Monocytes express the Interleukin-27 receptor and in respons... |
| _timestamp | 2017-05-18 13:29:07 |
| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
| literatureReference | [LiteratureReference:8950197] Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes [LiteratureReference:448414] WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 [LiteratureReference:8950744] Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity |
| modified | [InstanceEdit:9006421] Duenas, Corina, 2017-05-16 [InstanceEdit:9006617] Jupe, Steve, 2017-05-17 [InstanceEdit:9006733] Duenas, Corina, 2017-05-18 |
| text | Monocytes express the Interleukin-27 receptor and in response to Interleukin-27 induce Signal transducer and activator of transcription 1-alpha/beta (STAT1) and STAT3 phosphorylation (Pflanz et al. 2004). Interleukin-27 can induce formation of STAT1/STAT3 heterodimers (Guzzo et al. 2010, Hirahara et al. 2015). Nuclear factor NF-kappa-B (NFkB) is activated by Interleukin-27 stimulation in response to STAT1/STAT3 activation and is essential for Interleukin-27 to activate the production of cytokines (Guzzo et al. 2010). |
| (summation) | [Reaction:8950782] p-STAT1 binds p-STAT3 [Homo sapiens] |
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No pathways have been reviewed or authored by Monocytes express the Interleukin-27 receptor and in respons... (8950232)
