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Details on Person Interleukin-27 dissociates from Interleukin-27 receptor

Class:IdReaction:8950210
_displayNameInterleukin-27 dissociates from Interleukin-27 receptor
_doReleaseTRUE
_timestamp2017-09-12 14:31:57
authored[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
edited[InstanceEdit:9005965] Duenas, Corina, 2017-05-11
input[Complex:448431] IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:8950167] IL-27 Promotes Proliferation of Human Leukemic Cell Lines Through the MAPK/ERK Signaling Pathway and Suppresses Sensitivity to Chemotherapeutic Drugs
modified[InstanceEdit:8952840] Duenas, Corina, 2016-12-19
[InstanceEdit:9005636] Duenas, Corina, 2017-05-09
[InstanceEdit:9005964] Duenas, Corina, 2017-05-11
[InstanceEdit:9006072] Duenas, Corina, 2017-05-12
[InstanceEdit:9006348] Duenas, Corina, 2017-05-13
[InstanceEdit:9020957] Jupe, Steve, 2017-09-12
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameInterleukin-27 dissociates from Interleukin-27 receptor
output[Complex:448442] IL27:EBI3 [extracellular region] [Homo sapiens]
[Complex:1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] [Homo sapiens]
[Complex:8950163] IL27RA:JAK1 [plasma membrane] [Homo sapiens]
regulatedBy[NegativeRegulation:9006965] Negative regulation by 'IL27 [extracellular region]'
regulationReference[RegulationReference:9642281] Negative regulation by 'IL27 [extracellular region]' A role for IL-27p28 as an antagonist of gp130-mediated signaling
releaseDate2017-06-12
reviewed[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8951004] R-HSA-8950210.5
summation[Summation:8950764] Interleukin-27 heterodimer (IL27) binds a heterodimeric rece...
(hasEvent)[Pathway:9020956] Interleukin-27 signaling [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780646] Update Tracker - [Reaction:8950210] Interleukin-27 dissociates from Interleukin-27 receptor - v62:[addRegulator]
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No pathways have been reviewed or authored by Interleukin-27 dissociates from Interleukin-27 receptor (8950210)