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Details on Person Interleukin 35 (IL35) may presumably signal via a complex th...
| Class:Id | Summation:8950194 |
|---|---|
| _displayName | Interleukin 35 (IL35) may presumably signal via a complex th... |
| _timestamp | 2017-08-08 11:08:35 |
| created | [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 |
| literatureReference | [LiteratureReference:6809152] IL-12 family cytokines: immunological playmakers [LiteratureReference:6809142] The composition and signaling of the IL-35 receptor are unconventional |
| modified | [InstanceEdit:8985393] Varusai, Thawfeek, 2017-04-13 [InstanceEdit:8985450] Varusai, Thawfeek, 2017-04-16 [InstanceEdit:9015044] Varusai, Thawfeek, 2017-08-08 |
| text | Interleukin 35 (IL35) may presumably signal via a complex that includes Tyrosine protein kinase JAK1 (JAK1) and JAK2 associated with Interleukin 6 receptor beta subunit (IL6ST) and Interleukin 12 receptor beta 2 subunit (IL12RB2) (Collison et al. 2012). These JAKs are believed to phosphorylate Signal transducer and activator of transcription 1 (STAT) (Stark GR and Darnell JE, 2012). As the series of events that induces JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box. |
| (summation) | [BlackBoxEvent:8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated [Homo sapiens] [Complex:8951269] IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukin 35 (IL35) may presumably signal via a complex th... (8950194)
