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Details on Person SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Class:Id	Reaction:8949688
_displayName	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)
_doRelease	TRUE
_timestamp	2017-01-21 08:27:02
authored	[InstanceEdit:8949686] May, Bruce, 2016-11-28
catalystActivity	[CatalystActivity:8949689] calcium:sodium antiporter activity of SLC8B1 [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8949699] May, Bruce, 2016-11-28
edited	[InstanceEdit:8949686] May, Bruce, 2016-11-28
input	[SimpleEntity:8949220] Ca2+ [mitochondrial matrix] [SimpleEntity:2889072] Na+ [mitochondrial intermembrane space] [SimpleEntity:2889072] Na+ [mitochondrial intermembrane space] [SimpleEntity:2889072] Na+ [mitochondrial intermembrane space]
isChimeric	FALSE
literatureReference	[LiteratureReference:8951458] NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state [LiteratureReference:8951460] NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
modified	[InstanceEdit:8951477] May, Bruce, 2016-12-06 [InstanceEdit:8951827] May, Bruce, 2016-12-11 [InstanceEdit:8953486] May, Bruce, 2016-12-23 [InstanceEdit:8956349] May, Bruce, 2017-01-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)
output	[SimpleEntity:8949232] Ca2+ [mitochondrial intermembrane space] [SimpleEntity:2889083] Na+ [mitochondrial matrix] [SimpleEntity:2889083] Na+ [mitochondrial matrix] [SimpleEntity:2889083] Na+ [mitochondrial matrix]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8949716] R-HSA-8949688.2
summation	[Summation:8951808] NCLX catalyzes the exchange of 3-4 sodium ions from the inte...
(hasEvent)	[Pathway:8949215] Mitochondrial calcium ion transport [Homo sapiens]
(precedingEvent)	[Reaction:8949703] SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) [Homo sapiens]
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No pathways have been reviewed or authored by SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (8949688)