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Details on Person PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)

Class:Id	Reaction:8949649
_displayName	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)
_doRelease	TRUE
_timestamp	2017-01-22 03:58:38
authored	[InstanceEdit:8949670] May, Bruce, 2016-11-28
catalystActivity	[CatalystActivity:1299486] metalloendopeptidase activity of Mitochondrial processing peptidase [mitochondrial matrix]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8949656] May, Bruce, 2016-11-28
edited	[InstanceEdit:8949670] May, Bruce, 2016-11-28
input	[Complex:8949643] proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8949654] The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria
modified	[InstanceEdit:8953459] May, Bruce, 2016-12-22 [InstanceEdit:8953464] May, Bruce, 2016-12-22 [InstanceEdit:8953737] May, Bruce, 2016-12-27 [InstanceEdit:8956349] May, Bruce, 2017-01-21 [InstanceEdit:8956354] May, Bruce, 2017-01-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)
output	[Complex:8949645] C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949227] SMDT1 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949642] SMDT1 transit peptide [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:8949661] C2orf47:AFG3L2 binds the transit peptide of SMDT1 [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8949682] R-HSA-8949649.2
summation	[Summation:8953457] The mitochondrial endopeptidase PMPCA:PMPCB cleaves the tran...
(hasEvent)	[Pathway:8949664] Processing of SMDT1 [Homo sapiens]
(precedingEvent)	[Reaction:8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix [Homo sapiens] [BlackBoxEvent:8949659] AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU [Homo sapiens] [Reaction:8953461] SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex [Homo sapiens]
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No pathways have been reviewed or authored by PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (8949649)