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Details on Person Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane

Class:Id	BlackBoxEvent:8949609
_displayName	Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane
_doRelease	TRUE
_timestamp	2017-02-27 03:23:49
authored	[InstanceEdit:8949607] May, Bruce, 2016-11-26
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8949565] May, Bruce, 2016-11-27
edited	[InstanceEdit:8949607] May, Bruce, 2016-11-26
inferredFrom	[BlackBoxEvent:8953627] Formation of MIB complex containing the MICOS complex [Saccharomyces cerevisiae]
input	[EntityWithAccessionedSequence:8949572] DNAJC11 [mitochondrial outer membrane] [Homo sapiens] [Complex:1252247] SAM complex [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:1267968] HSPA9(1-679) [mitochondrial intermembrane space] [Homo sapiens] [EntityWithAccessionedSequence:8949578] TMEM11 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949588] APOO (MIC26) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949612] APOOL (MIC27) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949583] CHCHD3 (MIC19) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949568] CHCHD6 (MIC25) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949569] IMMT (MIC60) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949561] MIC13 (QIL1) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949616] MINOS1 (MIC10) [mitochondrial inner membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8949576] Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes [LiteratureReference:1267948] Conserved roles of Sam50 and metaxins in VDAC biogenesis [LiteratureReference:8949590] Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex [LiteratureReference:1267946] The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11 [LiteratureReference:8953596] MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization [LiteratureReference:8953630] QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology [LiteratureReference:8874896] The Oxidation Status of Mic19 Regulates MICOS Assembly [LiteratureReference:8949601] Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits [LiteratureReference:8953623] Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells [LiteratureReference:8953660] Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure [LiteratureReference:8953606] The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions [LiteratureReference:8955554] QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease [LiteratureReference:8955553] Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit [LiteratureReference:8961766] Uniform nomenclature for the mitochondrial contact site and cristae organizing system [LiteratureReference:8953652] Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System
modified	[InstanceEdit:8953527] May, Bruce, 2016-12-23 [InstanceEdit:8953545] May, Bruce, 2016-12-23 [InstanceEdit:8953677] May, Bruce, 2016-12-26 [InstanceEdit:8955563] May, Bruce, 2017-01-11 [InstanceEdit:8961780] May, Bruce, 2017-02-05 [InstanceEdit:8979398] May, Bruce, 2017-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane
output	[Complex:8949617] MIB [mitochondrial inner membrane] [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8955549] Harper, J Wade, 2017-01-11 [InstanceEdit:8961759] Kozjak-Pavlovic, Vera, 2017-02-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8949634] R-HSA-8949609.2
summation	[Summation:8953543] Assembly of the MICOS complex on the inner mitochondrial mem...
(hasEvent)	[Pathway:8949613] Cristae formation [Homo sapiens]
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