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Details on Person MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix

Class:Id	Reaction:8949178
_displayName	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix
_doRelease	TRUE
_timestamp	2017-01-21 08:25:51
authored	[InstanceEdit:8949206] May, Bruce, 2016-11-21
catalystActivity	[CatalystActivity:8949144] calcium channel activity of MCU complex [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8949163] May, Bruce, 2016-11-21
edited	[InstanceEdit:8949206] May, Bruce, 2016-11-21
input	[SimpleEntity:8949232] Ca2+ [mitochondrial intermembrane space]
isChimeric	FALSE
literatureReference	[LiteratureReference:8949218] Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter [LiteratureReference:8949222] A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter [LiteratureReference:8949731] Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex [LiteratureReference:8949758] Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition [LiteratureReference:8949730] Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death [LiteratureReference:8949739] Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane [LiteratureReference:8949763] MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter [LiteratureReference:8949781] MCU encodes the pore conducting mitochondrial calcium currents [LiteratureReference:8953320] The role of calcium in the regulation of mitochondrial metabolism [LiteratureReference:8953327] MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity [LiteratureReference:8949167] MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling [LiteratureReference:8953330] The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit [LiteratureReference:8956338] MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake [LiteratureReference:8956341] EMRE is an essential component of the mitochondrial calcium uniporter complex [LiteratureReference:8949723] CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter
modified	[InstanceEdit:8949686] May, Bruce, 2016-11-28 [InstanceEdit:8949791] May, Bruce, 2016-11-28 [InstanceEdit:8953323] May, Bruce, 2016-12-22 [InstanceEdit:8953333] May, Bruce, 2016-12-22 [InstanceEdit:8956349] May, Bruce, 2017-01-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix
output	[SimpleEntity:8949220] Ca2+ [mitochondrial matrix]
precedingEvent	[Reaction:8949145] VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space [Homo sapiens] [Reaction:8949649] PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) [Homo sapiens] [Reaction:8949661] C2orf47:AFG3L2 binds the transit peptide of SMDT1 [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8949242] R-HSA-8949178.2
summation	[Summation:8953319] The mitochondrial calcium uniporter (MCU) is a protein compl...
(hasEvent)	[Pathway:8949215] Mitochondrial calcium ion transport [Homo sapiens]
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No pathways have been reviewed or authored by MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (8949178)