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Details on Person MCU complex [mitochondrial inner membrane]

Class:Id	Complex:8949151
_displayName	MCU complex [mitochondrial inner membrane]
_timestamp	2017-01-21 08:25:33
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8949163] May, Bruce, 2016-11-21
hasComponent	[EntityWithAccessionedSequence:8949184] MCU [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949153] MCUB [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949180] MICU1 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8949227] SMDT1 [mitochondrial inner membrane] [Homo sapiens] [DefinedSet:8956344] MICU2,3 [mitochondrial inner membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8949154] MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics [LiteratureReference:8949196] MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism [LiteratureReference:8949167] MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling [LiteratureReference:8949218] Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter [LiteratureReference:8949222] A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter [LiteratureReference:8949723] CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter
modified	[InstanceEdit:8949791] May, Bruce, 2016-11-28 [InstanceEdit:8953464] May, Bruce, 2016-12-22 [InstanceEdit:8956349] May, Bruce, 2017-01-21
name	MCU complex Mitochondrial Calcium Uniporter
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8949239] R-HSA-8949151.1
(output)	[Reaction:8953461] SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex [Homo sapiens]
(physicalEntity)	[CatalystActivity:8949144] calcium channel activity of MCU complex [mitochondrial inner membrane]
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No pathways have been reviewed or authored by MCU complex [mitochondrial inner membrane] (8949151)