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Details on Person VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space

Class:Id	Reaction:8949145
_displayName	VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space
_doRelease	TRUE
_timestamp	2017-02-26 07:53:05
authored	[InstanceEdit:8953749] May, Bruce, 2016-12-27
catalystActivity	[CatalystActivity:8949199] calcium channel activity of VDAC1,2,3 [mitochondrial outer membrane]
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:8949163] May, Bruce, 2016-11-21
edited	[InstanceEdit:8953749] May, Bruce, 2016-12-27
inferredFrom	[Reaction:8949737] Vdac1 translocates calcium from the cytosol to the mitochondrial intermembrane space [Rattus norvegicus]
input	[SimpleEntity:74016] Ca2+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8949760] Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance [LiteratureReference:8949786] Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria [LiteratureReference:8949733] VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria [LiteratureReference:8953522] Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels
modified	[InstanceEdit:8949791] May, Bruce, 2016-11-28 [InstanceEdit:8951827] May, Bruce, 2016-12-11 [InstanceEdit:8953526] May, Bruce, 2016-12-23 [InstanceEdit:8956349] May, Bruce, 2017-01-21 [InstanceEdit:8979392] May, Bruce, 2017-02-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space
output	[SimpleEntity:8949232] Ca2+ [mitochondrial intermembrane space]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8949235] R-HSA-8949145.2
summation	[Summation:8951802] VDAC1, VDAC2, and VDAC3 are voltage dependent anion channels...
(hasEvent)	[Pathway:8949215] Mitochondrial calcium ion transport [Homo sapiens]
(precedingEvent)	[Reaction:8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix [Homo sapiens]
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No pathways have been reviewed or authored by VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space (8949145)