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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of HSP90 chaperone cycle for steroid hormone receptors (SHR)

Class:IdPathwayDiagram:8948992
_displayNameDiagram of HSP90 chaperone cycle for steroid hormone receptors (SHR)
_timestamp2024-03-05 04:56:05
created[InstanceEdit:8948993] Shamovsky, Veronica, 2016-11-19
height1757
modified[InstanceEdit:8951482] Shamovsky, Veronica, 2016-12-06
[InstanceEdit:8954159] Shamovsky, Veronica, 2017-01-05
[InstanceEdit:9032892] Shamovsky, Veronica, 2017-12-19
[InstanceEdit:9032893] Shamovsky, Veronica, 2017-12-19
[InstanceEdit:9032894] Shamovsky, Veronica, 2017-12-19
[InstanceEdit:9690531] Jassal, Bijay, 2020-06-02
[InstanceEdit:9690547] Jassal, Bijay, 2020-06-02
[InstanceEdit:9705894] Jassal, Bijay, 2020-11-03
[InstanceEdit:9706780] Jassal, Bijay, 2020-11-09
[InstanceEdit:9706849] Jassal, Bijay, 2020-11-09
[InstanceEdit:9725889] Jassal, Bijay, 2021-04-01
[InstanceEdit:9726435] Jassal, Bijay, 2021-04-07
[InstanceEdit:9726523] Jassal, Bijay, 2021-04-07
[InstanceEdit:9726677] Jassal, Bijay, 2021-04-08
[InstanceEdit:9863737] Matthews, Lisa, 2024-03-05
representedPathway[Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand [Homo sapiens]
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</Activators> <Properties> <displayName>ATP hydrolysis by HSP70</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15" reactomeId="3371503" points="662 348, 727 297, 786 260" position="727 297" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="16" points="616 377" /> <Input id="13" points="614 343" /> <Input id="17" points="694 380" /> </Inputs> <Outputs> <Output id="10" points="710 232" /> <Output id="18" points="908 236" /> </Outputs> <Properties> <displayName>STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="21" reactomeId="5618107" points="1035 263, 1038 282, 1038 309" position="1038 282" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="22" points="1077 233" /> <Input id="18" points="1012 254" /> </Inputs> <Outputs> <Output id="23" /> </Outputs> <Properties> <displayName>ATP binding to HSP90 triggers conformation change</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="92" reactomeId="5618105" points="1106 451, 1107 451, 1107 574" position="1107 451" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" points="1053 365" /> <Input id="93" points="1157 425" /> </Inputs> <Outputs> <Output id="94" /> </Outputs> <Properties> <displayName>FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="95" reactomeId="5618085" points="936 443, 936 471, 937 499" position="936 471" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" points="1014 365" /> <Input id="96" points="905 428" /> </Inputs> <Outputs> <Output id="97" /> </Outputs> <Properties> <displayName>FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="98" reactomeId="5618110" points="579 578, 580 577, 407 577" position="580 577" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="97" points="875 535" /> <Input id="99" stoichiometry="2" points="670 608" /> </Inputs> <Outputs> <Output id="16" points="589 405" /> <Output id="6" points="256 264" /> <Output id="105" points="327 577" /> </Outputs> <Properties> <displayName>p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="103" reactomeId="5618098" points="584 637, 583 637, 517 637" position="583 637" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="94" points="1043 609, 638 659" /> <Input id="99" stoichiometry="2" points="670 622" /> </Inputs> <Outputs> <Output id="16" points="597 405" /> <Output id="100" points="451 637" /> <Output id="6" points="258 264" /> </Outputs> <Properties> <displayName>p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="104" reactomeId="5618073" points="364 700, 320 700, 277 700" position="320 700" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="100" points="377 665" /> <Input id="107" points="405 700" /> </Inputs> <Outputs> <Output id="105" points="265 606" /> <Output id="128" points="237 730" /> </Outputs> <Activators> <Activator id="106" points="743 760, 319 734" /> </Activators> <Properties> <displayName>FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="108" reactomeId="5618099" points="607 1406, 607 1405, 773 1405" position="607 1405" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="542" points="558 1371" /> <Input id="109" points="416 1406" /> </Inputs> <Outputs> <Output id="546" /> </Outputs> <Properties> <displayName>NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="114" reactomeId="5618080" points="1050 1404, 1221 1404, 1296 1403" position="1221 1404" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="844" points="888 1239" /> <Input id="546" points="897 1404" /> <Input id="832" points="928 1043" /> <Input id="398" points="906 1576" /> </Inputs> <Outputs> <Output id="862" points="1371 1402" /> <Output id="873" points="1394 1441" /> <Output id="865" points="1391 1351" /> <Output id="864" points="1404 1516" /> </Outputs> <Activators> <Activator id="116" points="1164 1445" /> </Activators> <Properties> <displayName>HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="117" reactomeId="5618093" points="1682 1414, 1732 1414, 1791 1414" position="1732 1414" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="867" points="1656 1381" /> <Input id="868" points="1657 1414" /> </Inputs> <Outputs> <Output id="118" points="1873 1468" /> <Output id="123" points="1810 1334" /> <Output id="120" points="1829 1379" /> <Output id="119" stoichiometry="2" points="1857 1435" /> <Output id="122" points="1852 1404" /> <Output id="827" points="1836 1510" /> </Outputs> <Catalysts> <Catalyst id="868" points="1620 1434, 1732 1475" /> </Catalysts> <Activators> <Activator id="106" points="781 763, 1461 878, 1732 1161" /> </Activators> <Properties> <displayName>ATP hydrolysis by HSP90</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="305" reactomeId="9678925" points="664 928, 664 929, 737 929" position="664 929" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="306" points="624 890" /> <Input id="308" points="623 954" /> </Inputs> <Outputs> <Output id="307" /> </Outputs> <Properties> <displayName>NR3C1 binds NR3C1 agonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="394" reactomeId="9705925" points="727 1602, 729 1602, 827 1602" position="729 1602" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="395" points="622 1602" /> <Input id="396" points="713 1575" /> </Inputs> <Outputs> <Output id="398" /> </Outputs> <Properties> <displayName>Androgens binds AR (in the HSP90 chaperone complex)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="460" reactomeId="9705926" points="596 1682, 598 1682, 657 1682" position="598 1682" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="395" points="568 1623" /> <Input id="461" points="548 1682" /> </Inputs> <Outputs> <Output id="462" /> </Outputs> <Properties> <displayName>AR binds AR agonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="534" reactomeId="9706837" points="450 1602, 450 1602, 505 1567" position="450 1602" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="535" points="413 1602" /> <Input id="395" points="500 1602" /> </Inputs> <Outputs> <Output id="536" /> </Outputs> <Properties> <displayName>AR binds AR antagonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="830" reactomeId="9690534" points="681 1014, 761 1014, 858 1014" position="761 1014" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="308" points="636 996" /> <Input id="831" points="628 1025" /> </Inputs> <Outputs> <Output id="832" /> </Outputs> <Activators> <Activator id="307" points="786 961" /> </Activators> <Properties> <displayName>NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="835" reactomeId="9725885" points="729 1217, 731 1216, 809 1216" position="731 1216" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="841" points="722 1180" /> <Input id="842" points="667 1217" /> </Inputs> <Outputs> <Output id="844" /> </Outputs> <Properties> <displayName>P4 bind PGR (in the HSP90 chaperone complex)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="855" reactomeId="9725855" points="439 1457, 440 1457, 498 1457" position="440 1457" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="109" points="382 1427" /> <Input id="856" points="390 1465" /> </Inputs> <Outputs> <Output id="857" /> </Outputs> <Properties> <displayName>NR3C2 binds NR3C2 antagonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="869" points="1504 1406, 1532 1409" position="1518 1407" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="862" /> </Inputs> <Outputs> <Output id="868" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="871" points="1463 1516, 1578 1434" position="1520 1475" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="864" /> </Inputs> <Outputs> <Output id="868" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="872" points="1481 1351, 1574 1399" position="1527 1375" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="865" /> </Inputs> <Outputs> <Output id="868" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="874" points="1506 1447, 1561 1434" position="1533 1440" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="873" /> </Inputs> <Outputs> <Output id="868" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="875" reactomeId="9726509" points="252 1381, 253 1380, 302 1358" position="253 1380" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="109" points="287 1390" /> <Input id="876" points="212 1381" /> </Inputs> <Outputs> <Output id="877" /> </Outputs> <Properties> <displayName>NR3C2 binds fludrocortisone</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="948" reactomeId="9726580" points="620 1280, 620 1279, 670 1279" position="620 1279" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="949" points="569 1280" /> <Input id="842" points="609 1240" /> </Inputs> <Outputs> <Output id="951" /> </Outputs> <Properties> <displayName>PGR binds PGR agonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="950" points="516 1264, 513 947, 598 890" position="513 947" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="949" /> </Inputs> <Outputs> <Output id="306" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="1031" reactomeId="9726621" points="550 1134, 549 1132, 593 1132" position="549 1132" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1032" points="484 1134" /> <Input id="842" points="592 1197" /> </Inputs> <Outputs> <Output id="1034" /> </Outputs> <Properties> <displayName>PGR binds PGR antagonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="1033" points="428 1153, 447 1345, 460 1509, 368 1585" position="453 1427" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="1032" /> </Inputs> <Outputs> <Output id="535" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of HSP90 chaperone cycle for steroid hormone receptors (SHR) (8948992)
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