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Details on Person NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]

Class:Id	Complex:8948707
_displayName	NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
_timestamp	2016-11-15 21:06:27
compartment	[Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:8948706] Shamovsky, Veronica, 2016-11-15
hasComponent	[EntityWithAccessionedSequence:1604439] DTX4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3249366] NLRP4 [cytosol] [Homo sapiens] [Complex:2396004] STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:166251] IRF3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166251] IRF3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168379] p-S172-TBK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168379] p-S172-TBK1 [cytosol] [Homo sapiens] [Complex:3134799] STING:STING [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:3248021] K63polyUb-STING [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:3248021] K63polyUb-STING [cytoplasmic vesicle membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3249374] NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
modified	[InstanceEdit:8948737] Shamovsky, Veronica, 2016-11-15
name	NLRP4:DTX4:STING:p-S172-TBK1:IRF3
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8948708] R-HSA-8948707.1
(input)	[Reaction:8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 [Homo sapiens]
(output)	[Reaction:3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 [Homo sapiens]
(physicalEntity)	[CatalystActivity:8948711] ubiquitin-protein transferase activity of NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
(regulator)	[NegativeRegulation:3249388] Negative regulation by 'NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]'
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No pathways have been reviewed or authored by NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (8948707)