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Query author contributions in Reactome

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Details on Person Pellino1, 2 and possibly 3 are believed to directly catalyse...

Class:IdSummation:8948059
_displayNamePellino1, 2 and possibly 3 are believed to directly catalyse...
_timestamp2016-11-10 13:18:26
created[InstanceEdit:8948068] Jupe, Steve, 2016-11-10
literatureReference[LiteratureReference:451412] The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling
[LiteratureReference:451426] Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase
[LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation
[LiteratureReference:451417] Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation
[LiteratureReference:451409] Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases
textPellino1, 2 and possibly 3 are believed to directly catalyse polyubiquitylation of IRAK1 (Xiao et al. 2008; Butler et al. 2007; Ordureau et al. 2008). Following ubiquitination IRAK1 dissociates.
(summation)[BlackBoxEvent:8948066] K63polyUb-IRAK1 dissociates [Homo sapiens]
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No pathways have been reviewed or authored by Pellino1, 2 and possibly 3 are believed to directly catalyse... (8948059)
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