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Details on Person miR-20 microRNAs bind PTEN mRNA

Class:Id	Reaction:8945709
_displayName	miR-20 microRNAs bind PTEN mRNA
_doRelease	TRUE
_timestamp	2017-10-06 17:08:33
authored	[InstanceEdit:8944486] Orlic-Milacic, Marija, 2016-11-03
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8945695] Orlic-Milacic, Marija, 2016-11-07
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
input	[EntityWithAccessionedSequence:2318746] PTEN mRNA [cytosol] [Homo sapiens] [CandidateSet:8945696] miR-20 RISC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8943449] A coding-independent function of gene and pseudogene mRNAs regulates tumour biology [LiteratureReference:8943446] Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
modified	[InstanceEdit:8959458] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:8985729] Orlic-Milacic, Marija, 2017-04-19 [InstanceEdit:9005631] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9024717] Orlic-Milacic, Marija, 2017-10-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	miR-20 microRNAs bind PTEN mRNA
output	[Complex:8945707] miR-20 RISC:PTEN mRNA [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN [Homo sapiens] [Reaction:5632939] TP53 binds the PTEN promoter [Homo sapiens] [Reaction:8944078] EGR1 binds the PTEN gene promoter [Homo sapiens] [Reaction:8944099] Activated PPARG binds PTEN gene promoter [Homo sapiens] [Reaction:6807077] NR2E1 associated with transcription repressors binds PTEN promoter [Homo sapiens] [Reaction:8943780] SALL4 recruits NuRD to PTEN gene [Homo sapiens] [Reaction:8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter [Homo sapiens] [Reaction:8944026] SNAI1,SNAI2 bind the PTEN gene promoter [Homo sapiens] [Reaction:8944047] JUN binds the PTEN gene promoter [Homo sapiens] [Reaction:8944397] p-T69,T71-ATF2 binds PTEN gene promoter [Homo sapiens] [Reaction:8944420] MAF1 binds the PTEN gene promoter [Homo sapiens]
regulatedBy	[NegativeRegulation:8948543] Negative regulation by 'miR-20 RISC:PTENP1 mRNA [cytosol]' [NegativeRegulation:8948636] Negative regulation by 'miR-20 RISC:CNOT6L mRNA [cytosol]' [NegativeRegulation:8948638] Negative regulation by 'miR-20 RISC:VAPA mRNA [cytosol]'
regulationReference	[RegulationReference:9642222] Negative regulation by 'miR-20 RISC:PTENP1 mRNA [cytosol]' A coding-independent function of gene and pseudogene mRNAs regulates tumour biology [RegulationReference:9642640] Negative regulation by 'miR-20 RISC:CNOT6L mRNA [cytosol]' Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs [RegulationReference:9642913] Negative regulation by 'miR-20 RISC:VAPA mRNA [cytosol]' Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
releaseDate	2017-06-12
reviewed	[InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8945720] R-HSA-8945709.5
summation	[Summation:8945694] MicroRNAs miR-20a-5p and miR-20b-5p, encoded by MIR20A and M...
(hasEvent)	[Pathway:8943723] Regulation of PTEN mRNA translation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8944497] PTEN mRNA translation is negatively regulated by microRNAs [Homo sapiens]
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No pathways have been reviewed or authored by miR-20 microRNAs bind PTEN mRNA (8945709)