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Details on Person UniProt:Q0E8C8 Spn77Ba
| Class:Id | ReferenceGeneProduct:8944800 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri November 4 2016;chain:25-450 added on Fri November 4 2016 |
| _displayName | UniProt:Q0E8C8 Spn77Ba |
| _timestamp | 2023-11-03 15:40:58 |
| chain | signal peptide:1-24 chain:25-450 |
| checksum | C633F8960EE6F367 |
| comment | FUNCTION Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection (PubMed:18854145, PubMed:22227521). Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade (PubMed:18854145).SUBCELLULAR LOCATION Detected in the extracellular space at the apical surface of tracheal cells.DEVELOPMENTAL STAGE In larvae, highly expressed in the tracheal system. Weak expression is also detected in other larval tissues including the gut and epidermis.DISRUPTION PHENOTYPE RNAi-mediated knockdown results in spontaneous melanization of the tracheal system in larvae and pupae (PubMed:18854145, PubMed:22227521). Displays melanization at the 2nd or 3rd larval stage and affected larvae die a few days after it first occurs (PubMed:18854145). Melanization is first detected between tracheal cells and the overlying cuticle, then increases in intensity and spreads to the epithelial layer of the affected tracheal cells (PubMed:18854145). Increased expression of the antimicrobial gene Drs in the trachea and fat body (PubMed:18854145).SIMILARITY Belongs to the serpin family. |
| created | [InstanceEdit:8944791] Weiser, JD |
| description | recommendedName: fullName evidence="5"Serine protease inhibitor 77Ba shortName evidence="5"Serpin 77Ba |
| geneName | Spn77Ba CG6680 |
| identifier | Q0E8C8 |
| isSequenceChanged | FALSE |
| keyword | Glycoprotein Melanin biosynthesis Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Spn77Ba |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SP77B_DROME Q8IGD7 Q95SG7 |
| sequenceLength | 450 |
| species | [Species:56210] Drosophila melanogaster |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q0E8C8 Spn77Ba (8944800)
