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Details on Person UniProt:Q21412 parn-1
| Class:Id | ReferenceGeneProduct:8944799 |
|---|---|
| _chainChangeLog | chain:1-566 added on Fri November 4 2016 |
| _displayName | UniProt:Q21412 parn-1 |
| _timestamp | 2023-11-03 15:10:33 |
| chain | chain:1-566 |
| checksum | 8688937ED4C2E196 |
| comment | FUNCTION Involved in transcriptome surveillance. Required for piwi-interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro.COFACTOR Co-localizes with prg-1 in germline nuage structures called P granules.TISSUE SPECIFICITY Expressed in germline cells.DEVELOPMENTAL STAGE Expressed at low levels at the L1 to L3 larval stages, but begins to accumulate at the L4 stage and reaches its highest expression level at the gravid adult stage.DISRUPTION PHENOTYPE Slight changes of mRNA bulk poly(A) tail lengths (PubMed:23843623). Animals display a reduced brood size at elevated temperature of 25 degrees Celsius compared to wild-type (PubMed:23843623, PubMed:26919432). Accumulation of untrimmed piRNAs with 3' extensions, which are stable and able to co-localize with the piwi protein prg-1. However, while the expression levels of piRNAs remain unchanged, the piwi-dependent mRNA silencing is reduced, as is the production of piwi-dependent secondary small interfering RNAs (siRNAs), also called 22G-RNAs, on mRNA targets. 5'-end processing and methylation of 3'-ends are unaffected. No changes in length distribution of other small RNA species, such as microRNAs (miRNAs) (PubMed:26919432).SIMILARITY Belongs to the CAF1 family. |
| created | [InstanceEdit:8944791] Weiser, JD |
| description | recommendedName: fullName evidence="6"3'-5' exoribonuclease parn-1 alternativeName: fullName evidence="4 9"Poly(A)-specific ribonuclease homolog 1 alternativeName: fullName evidence="5"RNase parn-1 ecNumber evidence="3"3.1.13.- |
| geneName | parn-1 K10C8.1 |
| identifier | Q21412 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Exonuclease Hydrolase Magnesium Metal-binding Nuclease Reference proteome RNA-mediated gene silencing |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | parn-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PARN1_CAEEL |
| sequenceLength | 566 |
| species | [Species:68320] Caenorhabditis elegans |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q21412 parn-1 (8944799)
