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Details on Person UniProt:Q9D4G2 Hsf2bp
| Class:Id | ReferenceGeneProduct:8944793 |
|---|---|
| _chainChangeLog | chain:1-338 added on Fri November 4 2016 |
| _displayName | UniProt:Q9D4G2 Hsf2bp |
| _timestamp | 2024-08-09 19:39:51 |
| chain | chain:1-338 |
| checksum | FE18FF78A3A62D49 |
| comment | FUNCTION Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:30760716, PubMed:31242413, PubMed:32345962, PubMed:32463460). Required for proper recombinase recruitment in female meiosis (PubMed:30760716, PubMed:32845237). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (PubMed:23707421). May be involved in modulating HSF2 activation in testis (By similarity).SUBUNIT Interacts (via C-terminus) with BNC1 (PubMed:23707421). Associates with HSF2. The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP (By similarity). Interacts (via N-terminus) with BRME1 (PubMed:32345962, PubMed:32460033, PubMed:32463460). Interacts with BRCA2 and BRME1; the interactions are direct and allow the formation of a ternary complex (PubMed:30760716, PubMed:31242413, PubMed:32345962, PubMed:32460033, PubMed:32463460, PubMed:32845237). The complex BRME1:HSF2BP:BRCA2 interacts with SPATA22, MEIOB and RAD51 (PubMed:30760716, PubMed:32345962).INTERACTION Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes.TISSUE SPECIFICITY Expressed in testis and, to a lesser extent, in lung and muscle.DEVELOPMENTAL STAGE Detected at low levels from birth to 3 days post partum, thereafter the expression level increases from 5 days post partum to adult. In spermatocytes, shows punctate localization along chromosome axes specifically in early meiotic prophase I cells. Foci start to appear from the leptotene stage, reach their greatest number in the zygotene stage, persist until the early pachytene stage, and finally disappear in the late pachytene stage (PubMed:30760716).PTM Sumoylated by UBE2I in response to MEKK1-mediated stimuli.DISRUPTION PHENOTYPE Male mutants are infertile (PubMed:30760716, PubMed:31242413). They have smaller-than-normal testes with no sperm (PubMed:30760716, PubMed:31242413). Female mutants exhibit a fertility with 40% reduction in litter size compared to wild-type females. They show reduced follicle formation (PubMed:30760716, PubMed:32845237). Mutant oocytes show a delay in prophase I progression with the majority of cells at zygotene stage in 17.5 days post-coitum (dpc) females (PubMed:32845237). |
| created | [InstanceEdit:8944791] Weiser, JD |
| description | recommendedName: fullName evidence="17"Heat shock factor 2-binding protein |
| geneName | Hsf2bp Meilb2 |
| identifier | Q9D4G2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chromosome Coiled coil Cytoplasm Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Hsf2bp |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | HSF2B_MOUSE |
| sequenceLength | 338 |
| species | [Species:48892] Mus musculus |
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No pathways have been reviewed or authored by UniProt:Q9D4G2 Hsf2bp (8944793)
