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Details on Person UniProt:G5EFE7 fut-8
| Class:Id | ReferenceGeneProduct:8944792 |
|---|---|
| _chainChangeLog | chain:1-559 added on Fri November 4 2016 |
| _displayName | UniProt:G5EFE7 fut-8 |
| _timestamp | 2025-08-15 21:45:18 |
| chain | chain:1-559 |
| checksum | BBF6F1944A9BEF9F |
| comment | FUNCTION Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans (PubMed:15604090). The addition is prevented if the GlcNAc residue is already fucosylated (PubMed:15604090). Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds (PubMed:20062796).CATALYTIC ACTIVITY N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP-beta-L-fucose = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP + H(+)COFACTOR May also use Ca(2+). The enzyme has substantial activity without divalent cations.ACTIVITY REGULATION Inhibited by Fe(3+), Ni(2+) and Cu(2+).BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 6-7.5.PATHWAY Protein modification; protein glycosylation.SUBCELLULAR LOCATION Membrane-bound form in trans cisternae of Golgi.SIMILARITY Belongs to the glycosyltransferase 23 family. |
| created | [InstanceEdit:8944791] Weiser, JD |
| description | recommendedName: fullName evidence="3"Alpha-(1,6)-fucosyltransferase shortName evidence="1"Alpha1-6FucT ecNumber evidence="3 8"2.4.1.68 alternativeName: fullName evidence="13"Fucosyltransferase 8 alternativeName: fullName evidence="1"GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase alternativeName: fullName evidence="1"GDP-fucose--glycoprotein fucosyltransferase alternativeName: fullName evidence="1"Glycoprotein 6-alpha-L-fucosyltransferase |
| geneName | fut-8 C10F3.6 |
| identifier | G5EFE7 |
| isSequenceChanged | FALSE |
| keyword | Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Magnesium Manganese Membrane Metal-binding Reference proteome SH3 domain Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | fut-8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FUT8_CAEEL |
| sequenceLength | 559 |
| species | [Species:68320] Caenorhabditis elegans |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:G5EFE7 fut-8 (8944792)
