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Details on Person miR-21 nonendonucleolytic RISC binds PTEN mRNA

Class:Id	Reaction:8944706
_displayName	miR-21 nonendonucleolytic RISC binds PTEN mRNA
_doRelease	TRUE
_timestamp	2017-10-06 17:08:33
authored	[InstanceEdit:8944486] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8944702] Orlic-Milacic, Marija, 2016-11-04
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
input	[Complex:8944705] miR-21 Nonendonucleolytic RISC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2318746] PTEN mRNA [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8943408] MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer [LiteratureReference:8944704] MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)
modified	[InstanceEdit:8944714] Orlic-Milacic, Marija, 2016-11-04 [InstanceEdit:8959458] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:8985729] Orlic-Milacic, Marija, 2017-04-19 [InstanceEdit:9005631] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9024717] Orlic-Milacic, Marija, 2017-10-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	miR-21 nonendonucleolytic RISC binds PTEN mRNA
output	[Complex:8944703] miR-21 Nonendonucleolytic RISC:PTEN mRNA [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN [Homo sapiens] [Reaction:5632939] TP53 binds the PTEN promoter [Homo sapiens] [Reaction:8944078] EGR1 binds the PTEN gene promoter [Homo sapiens] [Reaction:8944099] Activated PPARG binds PTEN gene promoter [Homo sapiens] [Reaction:6807077] NR2E1 associated with transcription repressors binds PTEN promoter [Homo sapiens] [Reaction:8943780] SALL4 recruits NuRD to PTEN gene [Homo sapiens] [Reaction:8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter [Homo sapiens] [Reaction:8944026] SNAI1,SNAI2 bind the PTEN gene promoter [Homo sapiens] [Reaction:8944047] JUN binds the PTEN gene promoter [Homo sapiens] [Reaction:8944397] p-T69,T71-ATF2 binds PTEN gene promoter [Homo sapiens] [Reaction:8944420] MAF1 binds the PTEN gene promoter [Homo sapiens]
releaseDate	2017-06-12
reviewed	[InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8944708] R-HSA-8944706.3
summation	[Summation:8944712] miR-21-5p, one of the two mature products of miR-21, binds t...
(hasEvent)	[Pathway:8943723] Regulation of PTEN mRNA translation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8944497] PTEN mRNA translation is negatively regulated by microRNAs [Homo sapiens]
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No pathways have been reviewed or authored by miR-21 nonendonucleolytic RISC binds PTEN mRNA (8944706)