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Details on Person miR-19a microRNA binds PTEN mRNA

Class:Id	Reaction:8944522
_displayName	miR-19a microRNA binds PTEN mRNA
_doRelease	TRUE
_timestamp	2017-10-06 17:08:32
authored	[InstanceEdit:8944486] Orlic-Milacic, Marija, 2016-11-03
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8944521] Orlic-Milacic, Marija, 2016-11-03
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
input	[EntityWithAccessionedSequence:2318746] PTEN mRNA [cytosol] [Homo sapiens] [CandidateSet:8948559] miR-19a RISC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8943362] Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes [LiteratureReference:8943351] Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
modified	[InstanceEdit:8948101] Orlic-Milacic, Marija, 2016-11-10 [InstanceEdit:8948534] Orlic-Milacic, Marija, 2016-11-14 [InstanceEdit:8948573] Orlic-Milacic, Marija, 2016-11-14 [InstanceEdit:8959458] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:8985729] Orlic-Milacic, Marija, 2017-04-19 [InstanceEdit:9005631] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9024717] Orlic-Milacic, Marija, 2017-10-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	miR-19a microRNA binds PTEN mRNA
output	[Complex:8944524] miR-19a RISC:PTEN mRNA [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN [Homo sapiens] [Reaction:5632939] TP53 binds the PTEN promoter [Homo sapiens] [Reaction:8944078] EGR1 binds the PTEN gene promoter [Homo sapiens] [Reaction:8944099] Activated PPARG binds PTEN gene promoter [Homo sapiens] [Reaction:6807077] NR2E1 associated with transcription repressors binds PTEN promoter [Homo sapiens] [Reaction:8943780] SALL4 recruits NuRD to PTEN gene [Homo sapiens] [Reaction:8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter [Homo sapiens] [Reaction:8944026] SNAI1,SNAI2 bind the PTEN gene promoter [Homo sapiens] [Reaction:8944047] JUN binds the PTEN gene promoter [Homo sapiens] [Reaction:8944397] p-T69,T71-ATF2 binds PTEN gene promoter [Homo sapiens] [Reaction:8944420] MAF1 binds the PTEN gene promoter [Homo sapiens]
regulatedBy	[NegativeRegulation:8948600] Negative regulation by 'miR-19a RISC:VAPA mRNA [cytosol]' [NegativeRegulation:8948604] Negative regulation by 'miR-19a RISC:CNOT6L mRNA [cytosol]'
regulationReference	[RegulationReference:9641827] Negative regulation by 'miR-19a RISC:CNOT6L mRNA [cytosol]' Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs [RegulationReference:9642863] Negative regulation by 'miR-19a RISC:VAPA mRNA [cytosol]' Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
releaseDate	2017-06-12
reviewed	[InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8944527] R-HSA-8944522.5
summation	[Summation:8944523] MicroRNA miR-19a-3p, one of the two mature products of miR-1...
(hasEvent)	[Pathway:8943723] Regulation of PTEN mRNA translation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8944497] PTEN mRNA translation is negatively regulated by microRNAs [Homo sapiens]
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No pathways have been reviewed or authored by miR-19a microRNA binds PTEN mRNA (8944522)