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Details on Person PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN

Class:Id	BlackBoxEvent:8944104
_displayName	PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN
_doRelease	TRUE
_timestamp	2017-10-06 16:57:42
authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:8944105] Orlic-Milacic, Marija, 2016-11-02
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
inferredFrom	[BlackBoxEvent:6807098] Nr2e1 represses Pten transcription [Mus musculus]
input	[EntityWithAccessionedSequence:5632949] PTEN gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5632944] Regulation of PTEN transcription by p53 [LiteratureReference:5632991] p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas [LiteratureReference:8855919] The tumor suppressor PTEN interacts with p53 in hereditary cancer (Review) [LiteratureReference:8943330] The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling [LiteratureReference:8943341] Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN [LiteratureReference:6807074] Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1 [LiteratureReference:6808473] Transrepressive function of TLX requires the histone demethylase LSD1 [LiteratureReference:6808475] Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation [LiteratureReference:8943321] Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras [LiteratureReference:8944044] c-Jun promotes cellular survival by suppression of PTEN [LiteratureReference:8943309] Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis [LiteratureReference:8943317] SLUG is a direct transcriptional repressor of PTEN tumor suppressor [LiteratureReference:994203] Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex [LiteratureReference:8943798] Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex [LiteratureReference:8942896] SALL4 is a key regulator of survival and apoptosis in human leukemic cells [LiteratureReference:8943793] Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases [LiteratureReference:8942920] Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins [LiteratureReference:8942922] The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells [LiteratureReference:8943334] Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells [LiteratureReference:8944385] MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription
modified	[InstanceEdit:8944192] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8944206] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8944323] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8944401] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8944416] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8944445] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8944469] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8948097] Orlic-Milacic, Marija, 2016-11-10 [InstanceEdit:8959457] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:8979344] Orlic-Milacic, Marija, 2017-02-24 [InstanceEdit:9005631] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9024716] Orlic-Milacic, Marija, 2017-10-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN
output	[EntityWithAccessionedSequence:2318746] PTEN mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5632939] TP53 binds the PTEN promoter [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens] [Reaction:8944078] EGR1 binds the PTEN gene promoter [Homo sapiens] [Reaction:8944099] Activated PPARG binds PTEN gene promoter [Homo sapiens] [Reaction:6807077] NR2E1 associated with transcription repressors binds PTEN promoter [Homo sapiens] [Reaction:8943780] SALL4 recruits NuRD to PTEN gene [Homo sapiens] [Reaction:8943728] SALL4 binds the PTEN gene promoter [Homo sapiens] [Reaction:8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter [Homo sapiens] [Reaction:8943811] MECOM (EVI1) binds the PTEN gene promoter [Homo sapiens] [Reaction:8944026] SNAI1,SNAI2 bind the PTEN gene promoter [Homo sapiens] [Reaction:8944047] JUN binds the PTEN gene promoter [Homo sapiens] [Reaction:8944397] p-T69,T71-ATF2 binds PTEN gene promoter [Homo sapiens] [Reaction:168053] Phosphorylated MAPKs phosphorylate ATF-2 [Homo sapiens] [Reaction:8944420] MAF1 binds the PTEN gene promoter [Homo sapiens] [BlackBoxEvent:8944457] MAF1 translocates to the nucleus [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:6807078] Negative gene expression regulation by 'NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8943805] Negative gene expression regulation by 'SALL4:NuRD:PTEN gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8944035] Negative gene expression regulation by 'SNAI1,SNAI2:PTEN gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8944066] Negative gene expression regulation by 'JUN:PTEN gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8944083] Positive gene expression regulation by 'EGR1:PTEN gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8944185] Positive gene expression regulation by 'TP53 Tetramer:PTEN Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8944194] Positive gene expression regulation by 'PPARG:Fatty Acid Ligand:PTEN gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8944303] Negative gene expression regulation by 'MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8944413] Positive gene expression regulation by 'p-T69,T71-ATF2:PTEN gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8944446] Positive gene expression regulation by 'MAF1:PTEN gene [nucleoplasm]'
regulationReference	[RegulationReference:9641518] Negative gene expression regulation by 'SALL4:NuRD:PTEN gene [nucleoplasm]' Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex [RegulationReference:9641580] Negative gene expression regulation by 'SNAI1,SNAI2:PTEN gene [nucleoplasm]' Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis [RegulationReference:9641988] Positive gene expression regulation by 'EGR1:PTEN gene [nucleoplasm]' The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling [RegulationReference:9642231] Positive gene expression regulation by 'PPARG:Fatty Acid Ligand:PTEN gene [nucleoplasm]' Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN [RegulationReference:9642315] Negative gene expression regulation by 'NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm]' Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1 [RegulationReference:9642379] Negative gene expression regulation by 'MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm]' Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins [RegulationReference:9642431] Positive gene expression regulation by 'TP53 Tetramer:PTEN Gene [nucleoplasm]' Regulation of PTEN transcription by p53 [RegulationReference:9642810] Positive gene expression regulation by 'MAF1:PTEN gene [nucleoplasm]' MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription [RegulationReference:9642848] Positive gene expression regulation by 'p-T69,T71-ATF2:PTEN gene [nucleoplasm]' Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells [RegulationReference:9643022] Negative gene expression regulation by 'JUN:PTEN gene [nucleoplasm]' Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras
releaseDate	2017-06-12
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8855528] Orlic-Milacic, Marija, 2016-02-04
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8944106] R-HSA-8944104.5
summation	[Summation:5633003] PTEN (phosphatase and tensin homolog deleted in chromosome 1...
(hasEvent)	[Pathway:8943724] Regulation of PTEN gene transcription [Homo sapiens]
(precedingEvent)	[Reaction:2318752] miR-26A microRNAs bind PTEN mRNA [Homo sapiens] [Reaction:8944483] miR-17 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944522] miR-19a microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944538] miR-22 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944569] miR-25 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944599] miR-93 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944632] miR-106 microRNAs bind PTEN mRNA [Homo sapiens] [Reaction:8944650] miR-214 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944684] miR-205 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944706] miR-21 nonendonucleolytic RISC binds PTEN mRNA [Homo sapiens] List all 12 refering instances
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No pathways have been reviewed or authored by PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (8944104)