Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Binding of the transcription factor SALL4 to the PTEN gene p...

Class:IdSummation:8943803
_displayNameBinding of the transcription factor SALL4 to the PTEN gene p...
_timestamp2016-10-29 11:07:18
created[InstanceEdit:8943802] Orlic-Milacic, Marija, 2016-10-29
literatureReference[LiteratureReference:994203] Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex
[LiteratureReference:8943798] Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex
[LiteratureReference:8942896] SALL4 is a key regulator of survival and apoptosis in human leukemic cells
[LiteratureReference:8943793] Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases
textBinding of the transcription factor SALL4 to the PTEN gene promoter (Yang et al. 2008) and SALL4-medaited recruitment of the transcriptional repressor complex NuRD (Lu et al. 2009, Gao et al. 2013), containing histone deacetylases HDAC1 and HDAC2, inhibits the PTEN gene transcription. SALL4-mediated recruitment of DNA methyltransferases (DNMTs) is also implicated in transcriptional repression of PTEN (Yang et al. 2012).
(summation)[BlackBoxEvent:8943804] (delete)PTEN gene transcription is inhibited by SALL4:NuRD [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Binding of the transcription factor SALL4 to the PTEN gene p... (8943803)
Follow Reactome