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Details on Person UniProt:Q24324 Dsor1
| Class:Id | ReferenceGeneProduct:89436 |
|---|---|
| _chainChangeLog | chain:1-396 added on Fri February 6 2015 |
| _displayName | UniProt:Q24324 Dsor1 |
| _timestamp | 2025-02-21 19:27:12 |
| chain | chain:1-396 |
| checksum | 9245CED1DA750C33 |
| comment | FUNCTION Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Interacts with Raf and ksr; Dsor1 binding to ksr probably promotes ksr and Raf dimerization and ksr-mediated Raf transactivation.INTERACTION Expressed both maternally and zygotically.PTM Phosphorylation on Ser/Thr by MAP kinase kinase kinases regulates positively the kinase activity.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. |
| description | recommendedName: Dual specificity mitogen-activated protein kinase kinase dSOR1 shortName: Downstream of RAF shortName: MAPKK ecNumber: 2.7.12.2 |
| geneName | Dsor1 CG15793 |
| identifier | Q24324 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Developmental protein Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Tyrosine-protein kinase |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Dsor1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DSOR1_DROME Q8ISE0 Q9W360 |
| sequenceLength | 396 |
| species | [Species:56210] Drosophila melanogaster |
| (referenceEntity) | [EntityWithAccessionedSequence:205784] Phospho DSOR1 [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:205968] DSOR1 [cytosol] [Drosophila melanogaster] |
| (referenceSequence) | [ModifiedResidue:205874] O-phospho-L-serine at 241 [ModifiedResidue:206137] O-phospho-L-serine at 237 |
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No pathways have been reviewed or authored by UniProt:Q24324 Dsor1 (89436)
