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Details on Person A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

Class:Id	LiteratureReference:8943130
_displayName	A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
_timestamp	2016-10-24 08:06:02
author	[Person:8943063] van de Weijer, Michael L [Person:8933158] Bassik, Michael C [Person:8943128] Luteijn, Rutger D [Person:8943089] Voorburg, Cornelia M [Person:8943097] Lohuis, Mirjam A M [Person:75440] Kremmer, E [Person:8943064] Hoeben, Rob C [Person:8933156] Leproust, Emily M [Person:8933149] Chen, Siyuan [Person:8943124] Hoelen, Hanneke [Person:8943066] Ressing, Maaike E [Person:8943113] Patena, Weronika [Person:6786529] Weissman, Jonathan S [Person:8933157] McManus, Michael T [Person:8943065] Wiertz, Emmanuel J H J [Person:5686604] Lebbink, Robert Jan
created	[InstanceEdit:8943110] May, Bruce, 2016-10-24
journal	Nat Commun
pages	3832
pubMedIdentifier	24807418
title	A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
volume	5
year	2014
(literatureReference)	[BlackBoxEvent:8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 [Homo sapiens] [Reaction:8943083] US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP [Homo sapiens] [CatalystActivityReference:9643689] ubiquitin protein ligase activity of US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation [Complex:8943070] TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane] [Homo sapiens] [Complex:8943093] US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] [Homo sapiens] [Complex:8943101] TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:8943116] HLA A-2,A-3,B-60 [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:8943141] K48polyUb-HLA A-2,A-3,B-60 [endoplasmic reticulum membrane] [Homo sapiens]
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