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Details on Person The human cytomegalovirus US11 protein interacts with a MHC ...

Class:IdSummation:8943119
_displayNameThe human cytomegalovirus US11 protein interacts with a MHC ...
_timestamp2023-07-24 14:36:50
created[InstanceEdit:8943110] May, Bruce, 2016-10-24
modified[InstanceEdit:8955430] May, Bruce, 2017-01-11
[InstanceEdit:9840699] May, Bruce, 2023-07-24
textThe human cytomegalovirus US11 protein interacts with a MHC class I heavy chain and recruits the heavy chain to the TMEM129 E3 ubiquitin ligase complex comprising TMEM129, its cognate E2 conjugases UBE2J2 and UBE2K, and the VCP complex (VCP:VIMP) via the rhomboid pseudo-protease DERL1 (van de Weijer et al. 2014, van den Boomen et al. 2014, Flierman 2006, Lilley et al. 2004, Ye et al. 2004, Ye et al. 2001).
(summation)[Reaction:8943083] US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP [Homo sapiens]
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