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Details on Person TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I
| Class:Id | LiteratureReference:8943094 |
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| _displayName | TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I |
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| _timestamp | 2016-10-24 08:04:38 |
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| author | [Person:8943088] van den Boomen, Dick J H
[Person:8943122] Timms, Richard T
[Person:8943131] Grice, Guinevere L
[Person:8943076] Stagg, Helen R
[Person:8943107] Skødt, Karsten
[Person:8943060] Dougan, Gordon
[Person:8943109] Nathan, James A
[Person:8943082] Lehner, Paul J |
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| created | [InstanceEdit:8943110] May, Bruce, 2016-10-24 |
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| journal | Proc. Natl. Acad. Sci. U.S.A. |
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| pages | 11425-30 |
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| pubMedIdentifier | 25030448 |
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| title | TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I |
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| volume | 111 |
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| year | 2014 |
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| (literatureReference) | [CatalystActivityReference:9643689] ubiquitin protein ligase activity of US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
[Complex:8943070] TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane] [Homo sapiens]
[Complex:8943093] US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] [Homo sapiens]
[Complex:8943101] TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] [Homo sapiens]
[DefinedSet:8943116] HLA A-2,A-3,B-60 [endoplasmic reticulum membrane] [Homo sapiens]
[Complex:8943139] Ub:UBE2J2 [endoplasmic reticulum membrane] [Homo sapiens]
[DefinedSet:8943141] K48polyUb-HLA A-2,A-3,B-60 [endoplasmic reticulum membrane] [Homo sapiens]
[BlackBoxEvent:8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 [Homo sapiens]
[Reaction:8943083] US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP [Homo sapiens] |
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