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Details on Person The E3 ubiquitin ligase TMEM129 transfers ubiquitin from the...
| Class:Id | Summation:8943074 |
|---|---|
| _displayName | The E3 ubiquitin ligase TMEM129 transfers ubiquitin from the... |
| _timestamp | 2017-01-11 19:09:26 |
| created | [InstanceEdit:8943110] May, Bruce, 2016-10-24 |
| modified | [InstanceEdit:8955430] May, Bruce, 2017-01-11 |
| text | The E3 ubiquitin ligase TMEM129 transfers ubiquitin from the E2 ubiquitin conjugases UBE2J2 and UBE2K to a MHC class I heavy chain bound by the human cytomegalovirus US11 protein (van de Weijer et al. 2014, van den Boomen et al. 2014, Flierman et al. 2006, reviewed in van den Boomen and Lehner 2015). TMEM129 is located in the endoplasmic reticulum membrane in a complex containing DERL1, UBE2J2 and UBE2K, VIMP and VCP. After polyubiquitination, MHC class I heavy chain is retrotranslocated by the AAA ATPase VCP to the cytosol (Ye et al. 2001) where it is deglycosylated by NGLYI and degraded by the proteasome (Wiertz et al. 1996). US11 is released after the reaction and, if unable to bind another MHC I heavy chain, US11 is ubiquitinated by the HRD1-SEL1L E3 ubiquitin ligase complex and itself degraded by the proteasome (van den Boomen et al. 2014). This self-regulatory loop allows the amount of US11 in the cell to be buffered against the amount of MHC I molecules. |
| (summation) | [BlackBoxEvent:8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 [Homo sapiens] |
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