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Details on Person TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane]

Class:Id	Complex:8943070
_displayName	TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane]
_timestamp	2017-01-12 16:33:19
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8943110] May, Bruce, 2016-10-24
hasComponent	[EntityWithAccessionedSequence:6781898] DERL1 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8943134] TMEM129 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8943105] VCP [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8943099] VIMP [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8862601] UBE2J2-1 [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8943130] A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation [LiteratureReference:8943094] TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I
modified	[InstanceEdit:8955430] May, Bruce, 2017-01-11 [InstanceEdit:8955688] May, Bruce, 2017-01-12
name	TMEM129:DERL1:VIMP:VCP:UBE2J2
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8943165] R-HSA-8943070.1
(output)	[BlackBoxEvent:8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9899557] Update Tracker - [Complex:8943070] TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane] - v66:[updateContainedComponent]
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No pathways have been reviewed or authored by TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane] (8943070)