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Details on Person CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6

Class:Id	Reaction:8942836
_displayName	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
_doRelease	TRUE
_timestamp	2016-11-30 20:42:30
authored	[InstanceEdit:68869] Walworth, N, O'Donnell, M, 2003-06-05 [InstanceEdit:8942835] Orlic-Milacic, Marija, 2016-10-20
catalystActivity	[CatalystActivity:69222] protein serine/threonine kinase activity of CAK [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8942835] Orlic-Milacic, Marija, 2016-10-20
edited	[InstanceEdit:167002] Matthews, L, 2005-10-07 06:13:50 [InstanceEdit:8949902] Orlic-Milacic, Marija, 2016-11-30
input	[SimpleEntity:29358] ATP [nucleoplasm] [CandidateSet:8949874] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:182497] Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors" [LiteratureReference:8942850] A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression [LiteratureReference:8942858] Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation [LiteratureReference:8848459] p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes [LiteratureReference:8942863] CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point [LiteratureReference:8949888] Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase [LiteratureReference:8949887] Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation [LiteratureReference:8942879] Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase [LiteratureReference:8949889] Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation
modified	[InstanceEdit:8942845] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8942852] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8942859] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8942865] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8949883] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:8949891] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:8949892] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:8949900] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:8949904] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
output	[SimpleEntity:113582] ADP [nucleoplasm] [CandidateSet:8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus [Homo sapiens] [Reaction:8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes [Homo sapiens] [Reaction:8941895] Formation of CDK4/6:CCND complexes [Homo sapiens] [Reaction:8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes [Homo sapiens] [Reaction:8848436] PTK6 phosphorylates CDKN1B [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:165074] Manfredi, James J [InstanceEdit:8949903] Roger, Pierre P, 2016-11-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8942839] R-HSA-8942836.2
summation	[Summation:8942843] T-loop phosphorylation of CDK4 and CDK6 on threonine residue...
(hasEvent)	[Pathway:69231] Cyclin D associated events in G1 [Homo sapiens]
(precedingEvent)	[Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex [Homo sapiens] [Reaction:1226095] Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex [Homo sapiens] [Reaction:9754129] CDK6 inhibitors bind CDK6 [Homo sapiens] [Reaction:9754130] CDK4 inhibitors bind CDK4 [Homo sapiens]
(replacementInstances)	[_Deleted:8949936] Deletion of instance: 69223
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No pathways have been reviewed or authored by CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (8942836)