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Details on Person Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
Class:Id Reaction:8942607 _displayName Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes _doRelease TRUE _timestamp 2022-02-08 21:28:38 authored [InstanceEdit:8942612] Orlic-Milacic, Marija, 2016-10-18 catalystActivity [CatalystActivity:8942602] protein tyrosine kinase activity of (p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol] compartment [Compartment:70101] cytosol created [InstanceEdit:8942612] Orlic-Milacic, Marija, 2016-10-18 edited [InstanceEdit:8949902] Orlic-Milacic, Marija, 2016-11-30 input [Complex:8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] isChimeric FALSE literatureReference [LiteratureReference:8848452] Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases [LiteratureReference:8848424] Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4 [LiteratureReference:8942647] p57Kip2 is a downstream effector of BCR-ABL kinase inhibitors in chronic myelogenous leukemia cells [LiteratureReference:8942632] Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma [LiteratureReference:8942636] Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein [LiteratureReference:8848459] p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes [LiteratureReference:8942651] Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity [LiteratureReference:8942689] Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4 [LiteratureReference:8942769] Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control [LiteratureReference:8942792] p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 [LiteratureReference:8942801] Switching cyclin D-Cdk4 kinase activity on and off [LiteratureReference:8942879] Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase [LiteratureReference:8949844] Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4 [LiteratureReference:182497] Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors" [LiteratureReference:8949846] The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis [LiteratureReference:8949850] Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability modified [InstanceEdit:8942625] Orlic-Milacic, Marija, 2016-10-18 [InstanceEdit:8942626] Orlic-Milacic, Marija, 2016-10-18 [InstanceEdit:8942652] Orlic-Milacic, Marija, 2016-10-18 [InstanceEdit:8942691] Orlic-Milacic, Marija, 2016-10-19 [InstanceEdit:8942777] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8942799] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8942802] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8942881] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8949849] Orlic-Milacic, Marija, 2016-11-29 [InstanceEdit:8949854] Orlic-Milacic, Marija, 2016-11-29 [InstanceEdit:8949880] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:8949904] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:9764006] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes negativePrecedingEvent [NegativePrecedingEvent:9763995] Futile Cycle: PTK6 phosphorylates CDKN1B output [Complex:8942622] CDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C) [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] precedingEvent
releaseDate 2017-03-27 reviewed [InstanceEdit:8949903] Roger, Pierre P, 2016-11-04 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:8942613] R-HSA-8942607.3 summation [Summation:8942621] Phosphorylation of Cip/Kip cyclin-dependent kinase (CDK) inh... (hasEvent) [Pathway:69231] Cyclin D associated events in G1 [Homo sapiens] (precedingEvent) [BlackBoxEvent:8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus [Homo sapiens]
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