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Details on Person N-Acetylaspartylglutamate (NAAG) is found at high concentrat...

Class:IdSummation:8942567
_displayNameN-Acetylaspartylglutamate (NAAG) is found at high concentrat...
_timestamp2016-10-19 06:56:12
created[InstanceEdit:8942587] Jupe, Steve, 2016-10-18
literatureReference[LiteratureReference:8942562] N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate
[LiteratureReference:8942586] Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family
[LiteratureReference:8942572] Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase
modified[InstanceEdit:8942655] Jupe, Steve, 2016-10-19
textN-Acetylaspartylglutamate (NAAG) is found at high concentrations in the vertebrate nervous system. It is an agonist of group II metabotropic glutamate receptors. A number of other functions have been proposed for NAAG, including a role as a non-excitotoxic transport form of glutamate and a molecular water pump (Lodder-Gadaczek et al. 2011, Neale et al. 2011). NAAG is synthesized by N-acetylaspartylglutamate synthase A (RIMKLA, NAAG synthetase A) and Beta-citrylglutamate synthase B (RIMKLB, NAAG synthetase B), which more efficiently catalyzes the synthesis of beta-citryl-L-glutamate (Collard et al. 2010, Lodder-Gadaczek et al. 2011).
(summation)[Reaction:8942575] N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG [Homo sapiens]
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