Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Formation of CDK4/6:CCND complexes

Class:Id	Reaction:8941895
_displayName	Formation of CDK4/6:CCND complexes
_doRelease	TRUE
_timestamp	2018-12-21 21:00:43
authored	[InstanceEdit:182570] Matthews, L, 2006-07-03 08:41:56
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8941897] Orlic-Milacic, Marija, 2016-10-07
edited	[InstanceEdit:182570] Matthews, L, 2006-07-03 08:41:56 [InstanceEdit:8941900] Orlic-Milacic, Marija, 2016-10-07
input	[DefinedSet:69209] CDK4,CDK6 [cytosol] [Homo sapiens] [CandidateSet:182700] Cyclin D [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:77490] New functional activities for the p21 family of CDK inhibitors. [LiteratureReference:8941906] P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes [LiteratureReference:8941907] Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors [LiteratureReference:8941977] Identification of G1 kinase activity for cdk6, a novel cyclin D partner [LiteratureReference:8941974] Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins [LiteratureReference:8942875] Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1) [LiteratureReference:8942869] Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1) [LiteratureReference:8949552] Regulation of CDK4 [LiteratureReference:8949545] Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1) [LiteratureReference:8949555] A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes [LiteratureReference:8949553] CDK inhibitors: positive and negative regulators of G1-phase progression
modified	[InstanceEdit:8941909] Orlic-Milacic, Marija, 2016-10-07 [InstanceEdit:8941912] Orlic-Milacic, Marija, 2016-10-07 [InstanceEdit:8941919] Orlic-Milacic, Marija, 2016-10-07 [InstanceEdit:8941980] Orlic-Milacic, Marija, 2016-10-07 [InstanceEdit:8942686] Orlic-Milacic, Marija, 2016-10-19 [InstanceEdit:8942834] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8942877] Orlic-Milacic, Marija, 2016-10-20 [InstanceEdit:8949559] Orlic-Milacic, Marija, 2016-11-26 [InstanceEdit:8949904] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9632844] Rothfels, Karen, 2018-12-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of CDK4/6:CCND complexes
output	[Complex:8941896] CDK4,CDK6:CCND [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8853956] Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 [Homo sapiens] [Reaction:8853965] VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 [Homo sapiens] [BlackBoxEvent:9623355] ESR1-dependent CCND1 expression [Homo sapiens] [Reaction:9623341] p-S133 CREB1 dimer binds the CCND1 promoter [Homo sapiens] [BlackBoxEvent:9009378] Estrogen-responsive CCND1 gene expression [Homo sapiens] [Reaction:9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter [Homo sapiens]
regulatedBy	[NegativeRegulation:182599] Negative regulation by 'CDK4,CDK6:INK4 [cytosol]'
releaseDate	2016-12-12
reviewed	[InstanceEdit:8942662] D'Eustachio, Peter, 2016-10-19 [InstanceEdit:8949903] Roger, Pierre P, 2016-11-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8941898] R-HSA-8941895.5
summation	[Summation:8941910] The cyclin-dependent kinase CDK4 or CDK6 forms a complex wit...
(hasEvent)	[Pathway:69231] Cyclin D associated events in G1 [Homo sapiens]
(precedingEvent)	[Reaction:8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes [Homo sapiens] [BlackBoxEvent:8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus [Homo sapiens] [Reaction:9008412] CDK4 phosphorylates RUNX2 [Homo sapiens]
(replacementInstances)	[_Deleted:8949932] Deletion of instance: 69213
(updatedInstance)	[_UpdateTracker:9781579] Update Tracker - [Reaction:8941895] Formation of CDK4/6:CCND complexes - v60:[addLiteratureReference, modifyText] [_UpdateTracker:9953681] Update Tracker - [Reaction:8941895] Formation of CDK4/6:CCND complexes - v93:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by Formation of CDK4/6:CCND complexes (8941895)